Brief introduction of 5747-48-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5747-48-8,11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine,as a common compound, the synthetic route is as follows.

5747-48-8, In 5 mL of acetonitrile was dissolved 500 mg (1.693 mmol) of 11-piperazin-l- yldibenzo[b,f][l,4]thiazepine. In 5 mL of acetonitrile at room temperature was dissolved H3PO4 (85% assay; 163 mg, 1.693 mmol). The solutions were combined resulting in immediate precipitation of a slightly gummy solid. The solid did not redissolve upon reheating, but did triturate into a free-flowing solid. There was no change upon standing overnight. The solids were collected, washed with acetonitrile (5 mL) and dried under vacuum at 40 0C resulting in 588 mg (88.7 %) of ciystalline solid, nip 227-233 0C (dec). 1H NMR (DMSO-d6) was consistent with the title salt.Polarized light microscopy revealed the material to be composed of rod-shaped crystalline particles. DSC revealed a series of endothermic events at higher temperatures likely corresponding to melting and degradation (see Figure 9). The TGA also indicated slight water loss of 0.5% at 105 0C (see Figure 9). DVS revealed that the material was slightly hygroscopic (see Figure 10). The moisture gain was reversible with some hysteresis on the first cycle (characteristic of a channel hydrate). The cycles overlapped well with no evidence of form change.

The synthetic route of 5747-48-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; WO2007/62336; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics