With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.259808-67-8,1-Boc-3,3-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
8-tert-butyl-6-(4-fluorophenyl)imidazo[l,2-b]pyridazine-2-carboxylic acid (5g, 16 mmol), DMF (l20mL), HATU (7.3g, 19.2 mmol), tert-butyl 3, 3 -dimethylpiperazine-l -carboxylate (4.lg, 1.92 mmol) and DIPEA (lOmL, 57.4 mmol) afforded tert-butyl 4-(8-(tert-butyl)-6- (4-fluorophenyl)imidazo [l,2-b]pyridazine-2-carbonyl)-3 ,3 -dimethylpiperazine- 1 – carboxylate that was dissolved in 4N HC1 solution in l,4-dioxane (60 mL) affording 4-(8- (tert-butyl)-6-(4-fluorophenyl)imidazo[l,2-b]pyridazine-2-carbonyl)-3,3- dimethylpiperazine hydrochloride (6.5g, 97%) as a solid. 1H NMR (401 MHz, DMSO) d 9.71 (bs, 2H), 8.57 (s, 1H), 8.17 – 8.10 (m, 2H), 7.50 (s, 1H), 7.44 – 7.36 (m, 2H), 4.16 – 4.08 (m, 2H), 3.35 – 3.27 (m, 2H), 3.23 – 3.14 (m, 2H), 1.61 (s, 6H), 1.59 (s, 9H)., 259808-67-8
As the paragraph descriping shows that 259808-67-8 is playing an increasingly important role.
Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; AURELIO, Luigi; BUNNETT, Nigel; FLYNN, Bernard Luke; GIANG, Le; (125 pag.)WO2019/124567; (2019); A1;,
Piperazine – Wikipedia
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