192130-34-0, tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 69 (0.2 g, 0.57 mmol), 4-(2-amino-ethyl)-piperazine-l-carboxylic acidtert-butyl ester (0.26 g, 1.13 mmol) and DIEA (0.20 mL, 1.14 mmol) in 1-butanol (5 mL) washeated to 120¡ãC for 1.5 h. After concentration, the residue was purified by silica gelchromatography using 2-5percent MeOH/DCM, to give 4-[2-(5,6-diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-ethyl]-piperazine-l-carboxylic acid tert-butyl ester 71 (0.20 g). Compound 71 wassubjected to 20 mL of 20percent TFA/DCM at rt for 2 h, then the reaction was concentrated almostto dryness under reduced pressure, and purified by silica gel column chromatography using0.1percent MeOH/DCM containing ImL ammonium hydroxide, to give 72 (0.15 g). MS: 400.2(M+l). ‘HNMRtDMSO-dg) ppm 8.36 (s, 1H), 7.61-7.33 (m, 10H), 5.49 (t, 1H, J=4.48Hz),3.45 (dd, 2H, Jr=5.10Hz, J2=5.84Hz), 2.33 (t, 2H, J=5.80Hz), 2.13 (br, 4H), 1.95 (br, 1H)(note: some peaks overlapped with water peak in DMSO-de). ‘HNMR (CCla-d) ppm 8.43 (s,1H), 7.60-7.50 (m, 6H), 7.50-7.26 (m, 4H), 5.39 (t, 1H), 3.54 (dd, 2H, J^S.OSHz, J2=6.20Hz),2.73 (t, 4H, J=4.71Hz), 2.44 (t 2H, J=5.91Hz), 2.28 (br, 4H), 1,87 (br, 1H).
192130-34-0, As the paragraph descriping shows that 192130-34-0 is playing an increasingly important role.
Reference£º
Patent; AMGEN INC.; WO2006/4658; (2006); A2;,
Piperazine – Wikipedia
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