163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The compound (R) -4-Boc-2- methylpiperazine (528mg, 2.64mmol), glacial acetic acid (190mg, 3.16mmol), 1-ethyl-3- (3- Dimethylaminopropyl) carbodiimide hydrochloride (758mg, 3.95mmol) and N- hydroxy-7-azabenzotriazole(897mg, 6.59mmol) was dissolved In dichloromethane (20 mL), and under conditions of 0 C tothis solution was added dropwise N, N- diisopropylethylamine (1.8mL, 10.54mmol), stirred at roomtemperature Stirred 12h, was added water (10mL ¡Á 2) washing the organic phase was dried over anhydrous Na 2SO 4, the solvent was removed concentrate was separated by column chromatography (leaching Lotion: DCM /MeOH (v / v) = 40/1), to give 580mg colorless oil: Compound N- acetyl-4-tert-butoxycarbonyl -2- (R) – methylPiperazine, yield: 90%., 163765-44-4
The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
Piperazine – Wikipedia
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