163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 1 ,1-dimethylethyl (3R)-3-methyl-1-piperazinecarboxylate (301 mg, 1.5 mmol) in anhydrous acetonitrile (1OmL) was added PS-DIEA (925mg) and the solution was stirred gently under an argon atmosphere at room temperature for 15mins. 4-chlorobenzenesulfonyl chloride (371 mg, 1.8 mmol) as a solution in acetonitrile (5ml_) was added and the reaction was stirred for 24hrs. After this time, the reaction was filtered and PS-isocyanate (3g) was added to the solution which was stirred at room temperature over a weekend (approx 64hrs). The reaction was again filtered and PS-trisamine (1.2g) was added to the solution mixture which was stirred for 2hrs at room temperature. Finally the reaction was filtered and reduced in- vacuo to yield the title compound (411 mg, 73%).1H-NMR (CDCI3) 51.02 (3H, d, J= 6.8Hz), 1.43 (9H, s), 2.79 (1 H, br m), 2.97 (1 H, br m), 3.11 (1 H, dt J=12.5, 3.29Hz), 3.60 (1 H, m), 3.80 (1 H, br m), 4.1 1 (2H, br m), 7.48 (2H, m), 7.75 (2H, m)
163765-44-4, 163765-44-4 (R)-1-Boc-3-Methylpiperazine 2756811, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXO GROUP LIMITED; BESWICK, Paul, John; CAMPBELL, Alister; CRIDLAND, Andrew; GLEAVE, Robert, James; PAGE, Lee, William; WO2010/102663; (2010); A1;,
Piperazine – Wikipedia
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