Downstream synthetic route of 611225-86-6

611225-86-6 4-(4-Ethylpiperazin-1-ylmethyl)phenylamine 1084996, apiperazines compound, is more and more widely used in various fields.

611225-86-6,611225-86-6, 4-(4-Ethylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3.Synthesis of 4-[(4-ethylpiperazinyl)methyl]benzeneisothiocyanate To 4-[(4-ethylpiperazinyl)methyl]phenylamine in acetone at 0 C. was added sodium bicarbonate (2 eq) and thiophosgene (2 eq).The mixture was brought to ambient temperature and concentrated and partitioned between ethyl acetate and water.The organic layer was dried with sodium bicarbonate and sodium sulfate and concentrated to yield 4-[(4-ethylpiperazinyl)methyl]benzeneisothiocyanate. MS: MH+=261.

611225-86-6 4-(4-Ethylpiperazin-1-ylmethyl)phenylamine 1084996, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Amiri, Payman; Fantl, Wendy; Levine, Barry Haskell; Poon, Daniel J.; Ramurthy, Savithri; Renhowe, Paul A.; Subramanian, Sharadha; Sung, Leonard; US2004/122237; (2004); A1;,
Piperazine – Wikipedia
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