30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of the compound from example 11 (100 mg, 0.33 mmol) and 1-(4- trifluoromethylphenyl)piperazine (85 mg, 0.37 mmol) in DMF (0.5 mL) was added solid K2C03 (82 mg, 0.59 mmol). The resulting suspension was stirred at 90 C for 48 hours. Water (5 mL) and DCM (5 mL) were added and the phases were separated. Theaqueous phase was then extracted with further DCM (2 x 5 mL). The organics were dried over anh. Na2SO4, filtered and evaporated in vacuo to give a yellowish solid (161 mg). Column chromatography (Hexane/Ethyl acetate mixture) gave the title compound as a white solid (52 mg, 31.9% yield). The analytical sample was obtained by washing with cooled pentane (38 mg), m. p. 157-158 C. JR (ATR) v: 667, 711, 721, 744, 770,806, 824, 909, 951, 971, 984, 139, 1070, 1106, 1157, 1199, 1230, 1330, 1354, 1390,1429, 1493, 1522, 1594, 1615, 2847, 2919 cm1. Accurate mass: Calculated for [C28H29F2N4O+H]: 475.2294. Found: 475.2366.
30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CIDQO 2012, S.L.; UNIVERSITAT DE BARCELONA; VAZQUEZ CRUZ, Santiago; LEIVA MARTINEZ, Rosana; VALVERDE MURILLO, Elena; (60 pag.)WO2017/182464; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics