With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.
[0192] A suspension of intermediate 33 (0.10 g, 0.28 mmol), 4-(4-methyl-piperazin-l- ylmethyl)-phenylamine (65 mg, 0.32 mmol), Pd2(dba)3 (20 mg, 0.022 mmol), Xantphos (25 mg, 0.043 mmol) and cesium carbonate (0.18 g, 0.55 mmol) in dioxane/DMF (3/1, 4 mL) was sealed in a microwave reaction tube and irradiated with microwave at 170 C for 15 min. After cooling to room temperature, the cap was removed and the resulting mixture filtered and the filtered solid washed with DCM. The filtrate was concentrated and the residue purified by HPLC. The fractions were combined and poured into saturated NaHCO3 solution (30 mL). The combined aqueous layers were extracted with EtOAc (2 x 30 mL) and the combined organic layers washed with brine, dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated and the residue dissolved in minimum amount of EtOAc and hexanes added until solid precipitated. After filtration, the title compound was obtained as a white solid (53 mg, 36%).[0193] 1H NMR (500 MHz, DMSO-d6): delta 1.12 (s, 9H), 2.13 (s, 3H), 2.15 (s, 3H), 2.20- 2.45 (m, 4H), 3.25-3.40 (m, 6H), 7.08 (d, J= 8.6 Hz, 2H), 7.45-7.52 (m, 2H), 7.56 (s, IH), 7.57 (d, J= 8.6 Hz, 2H), 7.94 (s, IH), 8.09 (s, IH), 8.13-8.16 (m, IH), 8.58 (s, IH), 8.94 (s, IH). MS (ES+): m/z 524 (M+H)+.
70261-82-4, As the paragraph descriping shows that 70261-82-4 is playing an increasingly important role.
Reference£º
Patent; TARGEGEN, INC.; WO2007/53452; (2007); A1;,
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