With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.
A solution of 5-fluoro-2-nitroanisole (200 g, 1 eq) and piperazine (302 g, 3 eq) in DMF was stirred for 30 minutes and heated for 12 hours. Acetic anhydride (358 g, 3 eq) was slowly added to the reaction solution, and the reaction solution was stirred at room temperature for 12 hours. Water was added to the reaction solution for dilution, and the solid was filtered and washed twice with water. After drying at 50 C, the product was obtained as a yellow solid (284 g, 87%)., 13889-98-0
As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.
Reference£º
Patent; Anqing Yuanqi Pharmaceutical Technology Co., Ltd.; Jin Wei; Liu Jinlun; Wang Jianbing; (6 pag.)CN110294721; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics