288251-85-4, tert-Butyl 4-(4-amino-2-cyanophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of 21 3-(2,6-dichlorophenyl)-7-(methylthio)-2,3-dihydro-4H-pyrimido[5,4-e][1,3]oxazin-4-one (300 mg, 0.8767 mmol, 1.0 eq) in (10.0 mL) of 24 toluene was added 25 m-CPBA (376 mg, 2.1917 mmol, 2.5 eq) and allowed to stir at rt for 30 min followed by addition of 570 tert-butyl 4-(4-amino-2-cyanophenyl)piperazine-1-carboxylate (265 mg, 0.8767 mmol, 1 eq) and 27 DIPEA (452 mg, 3.506 mmol, 4.0 eq) and allowed to stir at rt for 12 h. The reaction mixture was diluted with water (50 mL) and extracted with EtOAc (2¡Á50 mL). The combined organic layers were washed with water (50 mL), brine (50 mL), dried over Na2SO4, concentrated and purified by flash chromatography (elution 0-35% 19 EtOAc in 20 Hexane) to afford the desired compound, 573 tert-butyl 4-(2-cyano-4-((3-(2,6-dichlorophenyl)-4-oxo-3,4-dihydro-2H-pyrimido[5,4-e][1,3]oxazin-7-yl)amino)phenyl)piperazine-1-carboxylate (150 mg, 28.68%) as an off white solid. (0600) LCMS: 596.2 [M+1]+, 288251-85-4
As the paragraph descriping shows that 288251-85-4 is playing an increasingly important role.
Reference£º
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
Piperazine – Wikipedia
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