With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129779-30-2,(3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Step 2: To a suspension of 26 (2.00 g, 7.3 mmol) in toluene (28 ml) were added N-Boc cis-2,6-dimethylpiperazine (3.13 g, 14.6 mmol), Pd2(dba)3 (254 mg, 0.28 mmol), tri-tert-butylphosphonium tetrafluoroborate (212 mg, 0.73 mmol) and NaO-tert-Bu (1.05 g, 10.9 mmol). The mixture was refluxed under N2 overnight. After cooling to room temperature, the mixture was partitioned between EtOAc (150 mL) and water (100 mL). The insoluble was removed through filtration and washed with EtOAc. The EtOAc layer was separated and washed with brine, dried over anhydrous Na2SO4. After the removal of organic solvent in vacuo, the residue was purified through Biotage chromatography (EtOAc/hexane= 25/100 to 75/100 gradient) to give the desired product 27 (476 mg, 16%) as a faint yellow solid.
129779-30-2, The synthetic route of 129779-30-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Jiang, Jian-kang; Huang, Xiuli; Shamim, Khalida; Patel, Paresma R.; Lee, Arthur; Wang, Amy Q.; Nguyen, Kimloan; Tawa, Gregory; Cuny, Gregory D.; Yu, Paul B.; Zheng, Wei; Xu, Xin; Sanderson, Philip; Huang, Wenwei; Bioorganic and Medicinal Chemistry Letters; vol. 28; 20; (2018); p. 3356 – 3362;,
Piperazine – Wikipedia
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