With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.
Synthesis of (4-(2-amino-9-(3-(4-ethylpiperazin-l-yl)propyl)-9H-purin-6-yl)piperazin-l- yl)(phenyl)methanone (18): Compound 17 was dissolved in acetonitrile (5 mL), potassium carbonate (1.2 g, 0.03 mmol) and phenyl(piperazine-l -yl) methanone (0.84 g, 0.03 mmol) were added. The reaction was stirred for 2 hours under N2 atmosphere condition at 100 C. Acetonitrile was evaporated under the vacuum, then water was added to the reaction mixture to get precipitate which was filter off to get precipitate (0.8 g, yield 70%) of product 18. 1H NMR (300 MHz, CDCI3) delta ppm 7.49 (s, 1H), 7.42 (d, J = 9 Hz, 4H), 4.63 (s, 2H), 4.26 (s, 3H), 4.09 (t, J = 6 Hz, 2H), 3.89 (s, 2H), 3.54 (s, 2H), 2.42 (d, J = 6 Hz, 8H), 2.28-2.40 (m, 3H), 1.85-2.03 (m, 3H), 1.08 (t, J = 6 Hz, 3H). ESI-MS m/z 478.34 (M+H)., 13754-38-6
13754-38-6 1-Benzoylpiperazine 762654, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; TALUKDAR, Arindam; GANGULY, Dipyaman; MUKHERJEE, Ayan; PAUL, Barnali; RAHAMAN, Oindrila; KUNDU, Biswajit; ROY, Swarnali; DEBLINA, Raychaudhuri; (60 pag.)WO2019/92739; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics