13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 81 2- [3 – (4- Acetyl-piperazin- 1 -yl) -phenyl] -6-chloro-3 ,3 -dimethyl- 1 ,2,3 ,4-tetrahydro- quinoline-8-carboxylic acidTo a mixture of 2-(3-bromo-phenyl)-6-chloro-3,3-dimethyl-l,2,3,4-tetrahydro-quinoline- 8-carboxylic acid methyl ester (410 mg, 1 mmol), palladium acetate (6.73 mg, 0.03 mmol), cesium carbonate (0.65 g, 2 mmol), xantphos (23 mg, 0.04 mmol) and N-acetylpiperazine (192 mg, 1.5 mmol) in toluene (10 mL) was stirred at 120C for 12 hours. Then the reaction mixture was concentrated in vacuo and the residue was extracted with ethyl acetate (2 x 100 mL), washed with saturated aqueous sodium chloride (2 x 50 mL), dried over anhydrous sodium sulfate and concentrated in vacuo. Purification on flash silica gel chromatography (silica gel from QingDao, 200-300 mesh, glass column from Shanghai SD company)(20% ethyl acetate/hexanes) to afford 2- [3-(4-acetyl-piperazin-l-yl)-phenyl] -6- chloro-3,3-dimethyl-l,2,3,4-tetrahydro-quinoline-8-carboxylic acid methyl ester (0.25 g, 54%) as a white solid: LC/MS m/e calcd for C25H30CIN3O3 M+: 455.99, observed: 456.1., 13889-98-0
As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; CHEN, Li; FENG, Lichun; HUANG, Mengwei; LIU, Yongfu; WU, Guolong; WU, Jim, Zhen; ZHOU, Mingwei; WO2011/128251; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics