With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.278788-66-2,(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
1-fluoro-4-nitrobenzene (1.056 g, 7.49 mmol) and potassium carbonate (3.10 g, 22.5 mmol) were suspended in anhydrous DMF (10 mL) . (R)-tert-butyl 3- (hydroxymethyl)piperazine-1-carboxylate (1.70 g, 7.86 mmol) was added and the mixture was heated at 90 C for21 h. After cooling the mixture was partitioned between brine/water (100 mL) and ethyl acetate (25 mL) . The aqueous layer was separated and further extracted with ethyl acetate (3 x 25 mL) . The combined ethyl acetate fractions were washed with brine/water (1:1, 4 x 25 mL),dried (Na2504), filtered and reduced in vacuo. The resulting residue was purified by silica gel chromatography (gradient 20-100% ethyl acetate in cyclohexane) to afford the title compound (0.69 g, 27.3LCMS (Method C) : = 1.38 mi m/z = 338 [M+H]., 278788-66-2
As the paragraph descriping shows that 278788-66-2 is playing an increasingly important role.
Reference£º
Patent; ALMAC DISCOVERY LIMITED; HARRISON, Timothy; TREVITT, Graham; HEWITT, Peter Robin; O’DOWD, Colin Roderick; BURKAMP, Frank; WILKINSON, Andrew John; SHEPHERD, Steven D.; MIEL, Hugues; WO2015/92431; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics