75336-86-6, (R)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,75336-86-6
Example 43.1: 2-((R)-3-Methyl-piperazin-l -yl)-nicotinonitrile. A mixture of (R)-2-methyl piperazine (507 mg, 5.06 mmol), 2-chloro-nicotinonitrile (1.05 g, 7.6 mmol), triethylaniine (2 mL, 14.3 mmol) and tetrahydrofuran (8 mL) was heated at 80¡ã C overnight. The reaction mixture was cooled to room temperature and aqueous saturated sodium bicarbonate (75 mL) was added. The mixture was extracted with dichloromethane (3×200 mL) and the combined organic layer washed with water (75 mL), washed with brine (75 mL), dried over sodium sulfate, filtered and concentrated. The residue was purified on silica gel using dichloromethane: 2M ammonia in methanol (95:5) to give 2- ((R)-3-methyl-piperazin-l-yl)-nicotinonitrile (964 mg, 94 percent). 1H NMR (300 MHz, CDCl3): delta(ppm) 8.34 (dd, IH), 7.77 (dd, IH), 6.74 (m, IH), 4.27 (m, 2H), 3.08 (m, 4H), 2.70 (m, IH), 1.15 (d, 3H).
The synthetic route of 75336-86-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; WO2008/112440; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics