With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of tert-butyl 3-(2-chloropyrimidin-4-yl)-5-fluoro-lH-indole-l- carboxylate (400 mg, 1.15 mmol) in dioxane (1 mL), were added cesium carbonate (2.25 g, 6.90 mmol), XANTPetaOS (39.8 mg, 0.069 mmol), l-(4-Amino-phenyl)-piperazine-4-carboxylic acid tert-butyl ester (604 mg, 1.72 mmol), and bis(dibenzylideneacetone)palladium (0) (21.1 mg, 0.023 mmol). The reaction mixture vial was capped and heated to 1000C for 12 hr. The reaction mixture was cooled, diluted with H2O, and extracted with EtOAc. The organic layer was collected, dried with MgSO4, filtered, and concentrated under reduced pressure. Column chromatography (100 % Hex to 100% EtOAc produced tert-butyl 3-[2-({4-[4-(tert- butoxycarbonyl)piperazin- 1 -yl]phenyl} amino)pyrimidin-4-yl]-5-fluoro- li/-indole- 1 -carboxylate. LRMS m/z (M+H) Calcd: 589.3, found: 589.3.
170911-92-9, The synthetic route of 170911-92-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK & CO., INC.; WO2007/149427; (2007); A2;,
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