13754-38-6, 1-Benzoylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
13754-38-6, General procedure: To a mixture of 1-benzoylpiperazine (1.0 eq) and potassium carbonate (2.0 eq) in dimethylformamide was added dropwise a solution of the corresponding substituted 9-bromo-9H-fluorene (1.0 eq) in dimethylformamide (The synthesis of 9-bromo-9H-fluorene derivatives is reported in supporting information). After stirring for 24 h at room temperature, solvent was removed and the crude residue was dissolved in diethyl ether, washed with brine, dried over magnesium sulfate,filtered and concentrated under vacuum. The residue was purified by flash chromatography as indicated in each case to afford the title compound. Reagents: 1-Benzoylpiperazine (0.08 mmol, 15 mg), potassium carbonate (0.15 mmol, 20 mg) and 9-bromo-3-hexyl-9H-fluorene (0.08 mmol, 25 mg). The crude product was purified by flash chromatography (isocratic, petroleum ether/ethyl acetate 70/30 in 15 min) to afford a yellow oil (18 mg, 56%). TLC Rf: 0.11 (petroleum ether/ethyl acetate 80/20). IR (cm-1): 630, 674, 697, 708, 739, 768, 787, 1001, 1015, 1142, 1155, 1255, 1277, 1301, 1424, 1447, 1633, 2854, 2925. HPLC: method 2, rt = 2.56 min, purity 97%. 1H NMR (300 MHz, CDCl3) delta (ppm): 0.85-1.00 (m, 3H); 1.29-1.48 (m, 6H); 1.62-1.77 (m, 2H); 2.46 (s, 2H); 2.72 (t, J = 7.5 Hz, 2H); 2.86 (s, 2H); 3.38 (s, 2H); 3.82 (s, 2H); 4.87 (s, 1H); 7.15 (dd, J = 1.5 Hz, 7.5 Hz, 1H); 7.32 (td, J = 1.5 Hz, 7.5 Hz, 1H); 7.35-7.48 (m, 6H); 7.53 (s, 1H); 7.55 (d, J = 5.4 Hz, 1H), 7.64 (d, J = 7.5 Hz, 1H); 7.70 (d, J = 7.5 Hz, 1H). 13C NMR (75 MHz, CDCl3) delta (ppm): 14.1 (CH3); 22.6 (CH2); 29.1 (CH2); 31.7 (CH2); 31.8 (CH2); 36.1 (CH2); 43.0 (CH2); 48.4 (CH2); 48.8 (CH2); 49.5 (CH2); 69.7 (CH); 119.7 (CH); 119.8 (CH); 125.6 (CH); 125.9 (CH); 127.0 (CH); 127.1 (2 * CH); 127.5 (CH); 128.2 (CH); 128.4 (2 * CH); 129.6 (CH); 135.9 (C); 140.7 (C); 141.1 (C); 141.2 (C); 143.3 (C); 143.8 (C); 170.3 (C). MS (DCI/CH4) m/z: 438.26 [M+H+], 249.16 [M-188]. HRMS (DCI/CH4): for C30H34N2O [M+H+]: calcd: 438.2671; found: 438.2674.
As the paragraph descriping shows that 13754-38-6 is playing an increasingly important role.
Reference£º
Article; Chollet, Aurelien; Mori, Giorgia; Menendez, Christophe; Rodriguez, Frederic; Fabing, Isabelle; Pasca, Maria Rosalia; Madacki, Jan; Kordulakova, Jana; Constant, Patricia; Quemard, Annaik; Bernardes-Genisson, Vania; Lherbet, Christian; Baltas, Michel; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 218 – 235;,
Piperazine – Wikipedia
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