21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
21655-48-1, A mixture of 2,5-dibromo-4-methylpyridine (3.5 g, 18.42 mmol), Hunig’s Base (9.63 mL,55.26 mmol) and (2R,6S)-2,6-dimethylpiperazine (2.314 g, 20.26 mmol) in DMSO (55 mL) was stirred at 110 ¡ãC for 18 hours. The reaction mixture was diluted with EtOAc (75 mL), and washed sequentially with water (2 x 50 mL) and saturated brine (25 mL). The organic layer was dried over MgSO4, filtered and concentrated to afford the crude (3S,5R)-1-(5-bromo-4-methylpyridin-2-yl)-3,5-dimethylpiperazine as an oil which crystallised on suanding to give a pale yellow solid (5.05 g, 96percent). Used with no further purification.
The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Holmes, Jane L.; Almeida, Lynsie; Barlaam, Bernard; Croft, Rosemary A.; Dishington, Allan P.; Gingipalli, Laksmaiah; Hassall, Lorraine A.; Hawkins, Janet L.; Ioannidis, Stephanos; Johannes, Jeffrey W.; McGuire, Thomas M.; Moore, Jane E.; Patel, Anil; Pike, Kurt G.; Pontz, Timothy; Wu, Xiaoyun; Wang, Tao; Zhang, Hai-Jun; Zheng, Xiaolan; Synthesis; vol. 48; 8; (2016); p. 1226 – 1234;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics