27469-60-9, 4,4-Difluorobenzhydrylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
[0103] Pivaloyl chloride (4.3 ml, 34.9 mmol) was added dropwise over 15 mins. at room temperature to a solution of [(S)-(+)-L-(TERT-BUTOXYCARBONYL)-2-] piperidinecarboxylic acid (8 g, 34.89 mmol) and triethylamine (12.5 ml, 90 mmol) in methylene chloride (150 ml). After stirring for 1.5 hrs. , a solution of [1-] [BIS- (4, 4′-DIFLUORO-BENZHYDRYL)] piperazine (9.51 g, 33 mmol) in methylene chloride (100 ml) was added over 1.5 hrs. and the reaction stirred at room temperature overnight. The reaction was washed with IN sodium hydroxide (2 x 100 ml) and brine and the organic layer dried over anhydrous sodium sulfate. After removal of solvent, the crude product was purified by chromatography (Silica gel) eluting with methylene chloride/ethyl acetate (7/3) to afford 16.5 g (quantitative yield) of the desired product.
27469-60-9, 27469-60-9 4,4-Difluorobenzhydrylpiperazine 152932, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Vertex Pharmaceuticals Incorporated; WO2004/31148; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics