163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The compound (R) -3- methyl-piperazine-1-carboxylate (500mg, 2.5mmol), isobutyric acid (263mg, 3.0mmol),1- ethyl 3- (3-dimethylaminopropyl) carbodiimide hydrochloride (957mg, 5.0mmol) and N- hydroxy-7-azabenzotriazole(507mg, 3.7mmol) It was dissolved in dichloromethane (10 mL), and the conditions under 0 C,to this solution was added dropwise N, N- diisopropylethylamine (1.3mL, 7.49mmol), chamber Temperature for10H, add water (10mL ¡Á 3), dried over anhydrous Na 2 SO 4 organic phase was dried, the solvent was removedconcentrate was separated by column chromatography (developing Degreasing agent: Petroleumether / EtOAc(v / v) = 2/1), to give 670mg white solid: (R) -4- isobutyryl-3- methyl-piperazine-1-carboxylic acid tert Butyl,yield: 99%., 163765-44-4
The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
Piperazine – Wikipedia
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