With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228780-72-0,1-((4′-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazine,as a common compound, the synthetic route is as follows.
(0142) A mixture of Compound 18A (1.7 g), Compound 3E (1.8 g), and HK2PO4 (1.21 g) in dimethylsulfoxide (20 ml) at 135 C. was stirred for 24 hours. The reaction was cooled, diluted with ether (400 ml), and washed with 3¡Á1M NaOH, and brine, and concentrated. The crude product was chromatographed on silica gel with 10-50% ethyl acetate/hexanes., 1228780-72-0
The synthetic route of 1228780-72-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AbbVie Inc.; Catron, Nathaniel; Lindley, David; Miller, Jonathan M.; Schmitt, Eric A.; Tong, Ping; US10213433; (2019); B2;,
Piperazine – Wikipedia
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