Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 5308-25-8, Name is 1-Ethylpiperazine, molecular formula is C6H14N2, belongs to piperazines compound, is a common compound. In a patnet, author is Giancola, JoLynn B., once mentioned the new application about 5308-25-8, Recommanded Product: 1-Ethylpiperazine.
Structure-activity relationships for a series of (Bis(4-fluorophenyl) methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the dopamine transporter: Bioisosteric replacement of the piperazine improves metabolic stability
Despite considerable efforts to develop medications to treat psychostimulant use disorders, none have proven effective, leaving an underserved patient population and unanswered questions as to what mechanism(s) of action should be targeted for developing pharmacotherapies. Atypical dopamine transporter (DAT) inhibitors, based on (+/-)modafinil, have shown therapeutic potential in preclinical models of psychostimulant abuse. However, metabolic instability among other limitations to piperazine analogues 1-3 have impeded further development. Herein, bioisosteric substitutions of the piperazine ring were explored with a series of aminopiperidines (A) and piperidine amines (B) wherein compounds with either a terminal tertiary amine or amide were synthesized. Several lead compounds showed high to moderate DAT affinities and metabolic stability in rat liver microsomes. Aminopiperidines 7 (DAT K-i = 50.6 nM), 21b (DAT K-i = 77.2 nM) and 33 (DAT K(i)Elsevier = 30.0 nM) produced only minimal stimulation of ambulatory activity in mice, compared to cocaine, suggesting an atypical DAT inhibitor profile. (C) 2020 Elsevier Masson SAS. All rights reserved.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 5308-25-8. The above is the message from the blog manager. Recommanded Product: 1-Ethylpiperazine.
Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics