In an article, author is Gong, Ningbo, once mentioned the application of 106261-49-8, Application In Synthesis of 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, Name is 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, molecular formula is C13H20Cl2N2O2, molecular weight is 307.22, MDL number is MFCD07772867, category is piperazines. Now introduce a scientific discovery about this category.
Crystal Structures, Stability, and Solubility Evaluation of a 2:1 Diosgenin-Piperazine Cocrystal
A cocrystal of diosgenin with piperazine in 2:1 stoichiometry was successfully synthesized. The solid form was prepared by liquid assisted grinding, slurry and crystallization methods. The cocrystal was characterized by powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, and structure determined by single crystal X-ray diffraction, the hydrogen bonds formed into fish bone structure along the [010] direction and all the molecules packed into 3D layer structure along a axis. After formation of cocrystal, the solubility of diosgenin was improved, and the solubility value in 0.2% SDS solution was approximately 1.5 times as large as that of the parent material. Graphic
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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics