170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
[0174] A mixture of intermediate 31 (0.20 g, 0.70 mmol) and 4-(4-amino-phenyl)- piperazine-1-carboxylic acid tert-bntyl ester (0.22 g, 0.79 mmol) in acetic acid (4 mL) was sealed in a microwave reaction tube and irradiated with microwave at 150 C for 15 min. After cooling to room temperature, the cap was removed and the mixture concentrated. The residue was purified by HPLC and the corrected fractions combined and poured into saturated NaHCO3 solution (40 mL). The combined aqueous layers were extracted with EtOAc (2 x 30 mL) and the combined organic layers washed with brine, dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated and the resulting solid dissolved in minimum amount of EtOAc and hexanes added until solid precipitated. After filtration, the title compound was obtained as an off white solid (0.10 g, 33%).[0175] 1H NMR (500 MHz, DMSO-d6): delta 2.10 (s, 3H), 3.16 (s, 8H), 3.73 (s, 3H), 6.83 (d, J= 9.0 Hz, 2H), 7.29 (d, J= 8.8 Hz, IH), 7.44 (dd, J = 8.7, 2.1 Hz, IH), 7.49-7.52 (m, 3H), 7.88 (s, IH), 8.32 (s, IH), 8.81 (s, IH) MS (ES+): m/z 425 (M+H)+.
170911-92-9, As the paragraph descriping shows that 170911-92-9 is playing an increasingly important role.
Reference£º
Patent; TARGEGEN, INC.; WO2007/53452; (2007); A1;,
Piperazine – Wikipedia
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