With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5747-48-8,11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine,as a common compound, the synthetic route is as follows.
Example 2 Preparation of l l-piperazin-l-yldibenzorfr7firi,4]thiazepine, dihydrochloride saltThe free base was converted to it’s dihydrochloride salt by dissolving it in a mixture of methanol (125 mL) and diethyl ether (125 mL), then treating with 250 mL of 1.0 M HCl/ ether (Aldrich). An off -white gummy solid separated initially, and the mixture was farther diluted with 50Q mL ether. The gummy solid did not solidify on prolonged stirring. The solvents were decanted away from the gum. The gum was treated with absolute ethanol (200 mL), then stirred until crystallization occurred, giving a thick white suspension of crystals. This mixture was then slowly diluted with ether (800 mL) and allowed to stir overnight to complete the crystallization. The crystalline dihydrochloride salt was isolated by filtration, washed with ether (3 X 50 mL), then dried in vacuum at 60 degrees C to afford the dihydrochloride salt of the title compound as a white crystalline solid (31.64 g, 98.8% conversion). EPO
The synthetic route of 5747-48-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; WO2006/73360; (2006); A1;,
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