103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 1-(2-hydroxyethyl)piperazine (651 mg, 5.00 mmol, 1.0 equiv.) in anhydrous tetrahydrofuran (15 mL) was added, at 000 under argon and dropwise, carbon disulfide (452 pL, 7.50 mmol, 1.5 equiv.). After 15 mm of stirring at 0C, sodium hydride (60% dispersion in mineral oil) (200 mg, 5.00 mmol, 1.0 equiv.) was added portionwise. After 40 mm of stirring at0C, the reaction mixture was concentrated in vacuo. The resulting crude product was washed several times with cyclohexane to eliminate mineral oil and then concentrated in vacuo et dried with a vane pump during one night to afford compound A083 (1.10 g, 4,82 mmol) as a pale yellow powder in 96 % yield which was used in the next step without further purification. 1H NMR (400 MHz, MeOD) 5 4.46 (t, J = 4.8 Hz, 4H, CH2N), 3.71 (t, J = 5.9 Hz,2H, CH2O), 2.55 (t, J = 5.1 Hz, 6H, CH2N). 130 NMR (100 MHz, MeOD) 5 60.98 (CH2N),59.80 (CH2O), 54.35 (CH2N), 51.20 (CH2N).
103-76-4, The synthetic route of 103-76-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; UNIVERSITE PARIS EST CRETEIL VAL DE MARNE; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); MOTTERLINI, Roberto; FORESTI, Roberta; MARTENS, Thierry; RIVARD, Michael; WO2015/140337; (2015); A1;,
Piperazine – Wikipedia
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