4318-42-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.
EXAMPLES; Intermediate 1; (1H-Indol-5-yl)-(4-isopropyl-piperazin-1-yl)-methanone; A mixture of 3.23 g (20 mmol) indole-5-caboxylic acid (commercially available), 3.07 g (24 mmol) 1-(2-propyl)-piperazine (commercially available), 8.03 g (25 mmol) TBTU and 10.3 mL (60 mmol) DIPEA in 50 mL DMF was stirred for 2 h at room temperature. After evaporation of all volatiles the residue was extracted with ethyl acetate, the combined organic layers dried with MgSO4 and evaporated to dryness. The residue was subsequently purified by flash column chromatography eluting with a mixture formed from DCM, MeOH and NH3 aq. to yield after evaporation of the combined product fractions 5.1 g (94percent) of the title compound as light brown foam. MS (m/e): 272.3 (MH+).
4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Nettekoven, Matthias; Roche, Olivier; US2008/188486; (2008); A1;,
Piperazine – Wikipedia
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