With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
Step 1: 3,5-Dimethyl-l-(4-trifluoromethoxy-bepizyl)-piperazine: To a solution of 4-(trifluoromethoxy)- benzaldehyde (776 muL, 4.38 mmol) in dichloromethane (30 mL) was added 2,6-dimethy. piperazine (1.0 g, 8.77mmol). The reaction mixture was stirred for Ih. Sodium triacetoxy borohydride (2.45 g, 8.77 mmol) was added and the reaction mixture was stirred for 4h. The reaction mixture was concentrated in vacuo, diluted with ethyl acetate and extracted with IN HCl (2 x 50 mL). The combined aqueous solution was neutralized with NaOH and extracted with ethyl acetate (3 x 50 mL). The combined organic solution was dried (Ts^SO,)) and concentrated in vacuo to provide 3,5-dimethyl-l-(4- trifluoromethoxy-benzyl)-piperazine (1.01 g, 80percent) as a clear oil. 1H NMR (400 MHz, CD3OD) delta 7.42 (d, 2H), 7.23 (d, 2H), 3.54 (s, 2H), 2.98-2.88 (m, 2H), 2.82-2.74,(m, 2H), 1.69 (t, 2H), 1.05 (d,6H); LCMS 289.5 (M+l)+.
21655-48-1, 21655-48-1 cis-2,6-Dimethylpiperazine 6950261, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; KALYPSYS, INC.; WO2007/47431; (2007); A2;,
Piperazine – Wikipedia
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