5271-27-2, 1-Methyl-3-phenylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5271-27-2, To a 300 L reactor was added 2-chloronicotinonitrile (13.86 kg, 100 mol), 1-methyl-3-phenylpiperazine (18.51 kg, 105 mol), potassium fluoride (17.42 kg, 300mol), dimethyl sulfoxide (DMSO) (100L), replaced with nitrogen three times, heated to 150 C, stirred for 2 hours. The reaction was completed by TLC, and direct distillation was carried out, and ethyl acetate 60 L was added to the residue. After centrifugation, 20 L of methanol, oxalic acid (12.6 kg, 100 mol) was added to the filtrate, and the mixture was stirred at 15-25 C for 6 hours, and filtered to give a pale yellow solid, 36.5 kg, yield 99%.
As the paragraph descriping shows that 5271-27-2 is playing an increasingly important role.
Reference£º
Patent; Beijing Ha Sanlian Science And Technology Co., Ltd.; Harbin Sanlian Pharmaceutical Co., Ltd.; Li Yuanzhen; Yu Hai; Ning Ruibo; (9 pag.)CN109988148; (2019); A;,
Piperazine – Wikipedia
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