259808-67-8, 1-Boc-3,3-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Tert-butyl 3,3-dimethylpiperazine-1-carboxylate (CAS 259808-67-8, 300 mg, 1.40 mmol), 2- chloropyrimidine (CAS 1722-12-9, 240 mg, 2.10 mmol), potassium fluoride (122 mg, 2.10 mmol) and TEA (0.389 mL, 2.80 mmol) were dissolved in DMF (3 mL). After flushing with argon, the solution was heated in a microwave reactor for 3 h at 80C, 6h at 100C, 6 h at 120C and 10 h at 140C.After cooling to rt the crude mixture was extracted with EtOAc (2x10mL) and water. The combined organic phases were washed with 1M HCI (aq), dried over Mg504 and evaporated to give crude tert-butyl 3,3-dimethyl-4-(pyrimidin-2-yl)piperazine-1- carboxylate., 259808-67-8
The synthetic route of 259808-67-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ACTURUM LIFE SCIENCE AB; SVENSSON, Mats A; WEIGELT, Dirk; WO2014/184248; (2014); A2;,
Piperazine – Wikipedia
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