With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-07-7,1-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.
59702-07-7, A mixture of 3-bromomethylbenzoic acid (4.30 g, 20 mmol), 1-methylpiperazin-2-one (2.3 g, 20 mmol),38 and powdered potassiumcarbonate (2.76 g, 20 mmol) in ethanol (50 mL) was stirredfor 17 h at room temperature. The solvent was evaporated off underreduced pressure to give a residue which was treated with HCl(10 mL of 2 M) and extracted with EtOAc. The combined extractswere washed with water, dried and the solvent was evaporatedoff under reduced pressure to give 8, which was recrystallised fromEtOAc/hexane to give a cream crystalline solid, mp 161?166 C; 1HNMR (DMSO-d6) d 2.63 (t, J = 5.5 Hz, 2H), 2.80 (s, 3H), 2.96 (s, 2H),3.26 (t, J = 5.5, 2H), 3.61 (s, 2H), 7.46 (d, J = 8.0 Hz, 2H), 7.90 (d,J = 8.0 Hz, 2H), 12.9 (br s, 1H).
59702-07-7 1-Methylpiperazin-2-one 4399042, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Manley, Paul W.; Blasco, Francesca; Mestan, Ju?rgen; Aichholz, Reiner; Bioorganic and Medicinal Chemistry; vol. 21; 11; (2013); p. 3231 – 3239;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics