With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109384-27-2,1-Methylpiperazin-2-one hydrochloride,as a common compound, the synthetic route is as follows.
109384-27-2, HATU (0.138 g, 0.363 mmol) was added to a mixture of 3-chloro-6-(3- furanyl)-8-(trifluoromethyl)imidazo[1 ,2-a]pyridine-2-carboxylic acid (0.1 00 g, 0.302 mmol), 1 -methyl-2-piperazinone hydrochloride (0.045 g, 0.302 mmol) and DIPEA (0.1 1 mL, 0.605 mmol) in DMF (1.5 mL). The mixture was stirred at room temperature overnight, The reaction mixture was diluted with ethyl acetate and washed with water. The organic layer was dried over sodium sulfate and the solvent was evaporated. The residue was purified by reverse phase HPLC (acetonitrile:water with 0.1 % formic acid) to afford 0.055 g of the title compound as a white solid. 1H NMR (400 MHz, DMSO-G(6) delta ppm 8.83 (d, J=6.96 Hz, 1 H) 8.58 (s, 1 H) 8.23 (s, 1 H ) 7.85 (s, 1 H) 7.34 (s, 1 H ) 4.46 (s, 1 H) 4.23 (s, 1 H) 4.05 (br. s., 1 H) 3.93 (br. s., 1 H ) 3.43 (m, 2 H) 2.91 (s, 3 H). ES-LCMS m/z: 426 (M+).
As the paragraph descriping shows that 109384-27-2 is playing an increasingly important role.
Reference£º
Patent; GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John, G.; CHONG, Pek, Yoke; FANG, Jing; GARRIDO, Dulce, Maria; PEAT, Andrew, James; PRICE, Daniel, J.; SHOTWELL, John, Brad; TAI, Vincent; ZHANG, Huichang; WO2011/41713; (2011); A2;,
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