57260-70-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57260-70-5,tert-Butyl 4-benzylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
The mixture of haloalkyl-5-benzhydryl-1H-tetrazole, 10a(300 mg, 1 mmol), alkylpiperazine, 13a (264, 1.5 mmol), K2CO3(276 mg, 2 mmol), NaI (catalyst) and CH3CN (15 mL) was refluxed. After the completion, reaction mixture was cooled, filtered and concentrated. The obtained product was purified by column chromatographyon silica gel with n-hexane: EtOAc: MeOH (10:1.5:0.5)to obtain 2a (131 mg, 30%) as light brown liquid. Rf = 0.56 (n-hexane:EtOAc: MeOH = 2.5:1.5:1). 1H NMR (500 MHz, CDCl3): d 7.35-7.24 (m, 15H), 5.84 (s, 1H), 4.72-4.69 (m, 2H), 3.49 (s, 2H), 3.04-2.97 (m, 2H), 2.53-2.42 (m, 8H); 13C NMR (125 MHz, CDCl3): d167.7, 140.9, 138.0, 129.2, 128.8, 128.6, 128.2, 127.1, 127.0, 63.0,56.4, 52.9, 52.8, 50.5, 48.6.
As the paragraph descriping shows that 57260-70-5 is playing an increasingly important role.
Reference£º
Article; Paudel, Suresh; Acharya, Srijan; Yoon, Goo; Kim, Kyeong-Man; Cheon, Seung Hoon; Bioorganic and Medicinal Chemistry; vol. 25; 7; (2017); p. 2266 – 2276;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics