1403898-64-5, (2R,5R)-tert-Butyl 5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A stirred solution of 113 7-bromo-4,6-dichloro-8-fluoro-3-nitroquinoline (2 g, 5.88 mmol) and 180 tert-butyl (2R,5R)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate (1.355 g, 5.88 mmol) in 142 MeCN (30 mL) was treated with 56 DIPEA (1.025 mL, 5.88 mmol) and the reaction mixture stirred at 80 C. for 75 min. The reaction mixture was concentrated in vacuo and purified by flash silica chromatography (0 to 40% 57 EtOAc in 58 heptane) to give 444 tert-butyl (2R,5R)-4-(7-bromo-6-chloro-8-fluoro-3-nitroquinolin-4-yl)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate (2.6 g, 83%) as a yellow solid; m/z: ES+ [M+H]+ 533/535.
1403898-64-5, The synthetic route of 1403898-64-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; Kettle, Jason Grant; Bagal, Sharanjeet; Robb, Graeme Richard; Smith, James Michael; Goldberg, Frederick Woolf; Cassar, Doyle Joseph; Feron, James Lyman; US2019/177338; (2019); A1;,
Piperazine – Wikipedia
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