With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.181955-79-3,1,4-Di-Boc-piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.
1,4-Di(tert-butoxycarbonyl)piperazine-2-carboxylic acid (14 g, 42.37 mmol) was sequentially added to a dry reaction flask.Potassium carbonate (11.7 g, 84.7 mmol),Acetone (200mL),Methyl iodide (5.3 mL, 85 mmol),Stir at room temperature for 12 h.Filtration, the filtrate was evaporated under reduced pressure, and the residue was diluted with EA (200 mL) and water (200 mL), and the organic phase was washed with saturated brine.Dry, dry anhydrous sodium sulfate, concentrated under reduced pressure,The title compound was obtained as a white solid (13.55 g, 93%)., 181955-79-3
The synthetic route of 181955-79-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Xinchang; Ren Qingyun; Yan Guanghua; S ¡¤geerdeman; Zhang Yingjun; (200 pag.)CN109678859; (2019); A;,
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