With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.
31166-44-6, A mixture of benzyl piperazine-1-carboxylate (Aldrich, 3.19 g, 14.5 mmol), 1-(5-fluoro-2-nitrobenzylsulfonyl)naphthalene (5.00 g, 14.5 mmol), and K2CO3 (4.00 g, 29.0 mmol) in DMF (32 mL) was stirred at 100¡ã C. for 3 hours, cooled to room temperature, diluted with water, and extracted with EtOAc. The organic layer was washed with water (3*), dried over Na2SO4, and concentrated in vacuo to provide the title compound (7.82 g, 94percent), characterized by NMR and mass spectral analyses. MS (ES+) m/e 546 (MH+).
As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.
Reference£º
Patent; Wyeth; US2009/318470; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics