74879-18-8, (S)-(+)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,74879-18-8
To a solution of 2-chloronicotinonitrile (3.0 g, 21.7 mmol) and (S)-2-methylpiperazine (2.17 g, 21.7 mmol) in DMF (10 mL) was added K2C03 (9.0 g, 65.1 mmol). The mixture was stirred at 120 C for 17 h. The solution was diluted with water (20 mL) and extracted with DCM (50 mL x 3). The organic phases were dried (Na2504), filtered, and concentrated in vacuo to afford (S)-2-(3-methylpiperazin-1-yl)nicotinonitrile (3.03 g, 80%) as yellow oil. ESI-MS (EI+, m/z: 203 [M+H].
The synthetic route of 74879-18-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NAVITOR PHARMACEUTICALS, INC.; O’NEILL, David John; SAIAH, Eddine; KANG, Seong Woo Anthony; BREARLEY, Andrew; BENTLEY, Jonathan; (565 pag.)WO2018/89433; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics