128102-16-9, (R)-4-Benzyl 1-Boc-2-methylpiperazine-4-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A second lot was prepared analogously with the insertion of an additional extraction step for further purification of the 1-tert-butyloxycarbonyl-2-methyl-4-benzyloxycarbonylpiperazine, to yield approximately 38 gallons of solution. This lot was identical to the first lot as assayed. A 50 gallon glass-lined reactor (set up for hydrogenation) was purged with nitrogen and charged with 2.0 kg of dry 10% palladium on carbon. About one-half of the first lot of 1-tert-butyloxycarbonyl-2-methyl-4-benzyloxycarbonylpiperazine (in methanol) was charged to the 50 gallon reactor (in this case 131 lbs of solution). The reaction was further diluted by the addition of another 656 lbs of methanol to the 50 gallon reactor. The reactor was purged several more times with nitrogen and then hydrogen, and cooling water was then circulated in the reactor jacket. The reactor was pressurized to 50 psi with hydrogen and agitate vigorously for one hour. The reactor was depressurized and then repressurized with hydrogen to 50 psi. The agitation was started again and this procedure of depressurizing and repressurizing continued until the reaction was complete. At the completion point of the reaction, the reactor was purged twice with nitrogen and the catalyst was filtered from the reaction mixture. The reactor and catalyst were rinsed with methanol. The solvent was removed at 45 +- 5C (25-28 mm Hg) to yield the title compound. 300 MHz 1H NMR (CDCl3) 4.17 (br m, 1H), 3.78 (br m, 1H), 3.0-2.6 (mm, 6H), 1.48 (s, 9H), 1.21(d, 3H)., 128102-16-9
The synthetic route of 128102-16-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ABBOTT LABORATORIES; EP350950; (1990); A1;,
Piperazine – Wikipedia
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