129799-15-1, Methyl 1-Boc-piperazine-2-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,129799-15-1
A mixture of (S) -5- (1- ( (tert-butoxycarbonyl) amino) ethyl) -2- (3- (cyclopropylmethoxy) -4- (difluoromethoxy) phenyl) oxazole-4-carboxylic acid (0.25 g, 0.53 mmol) , 1-tert-butyl 2-methyl piperazine-1, 2-dicarboxylate (157 mg, 0.64 mmol) , EDCI (153 mg, 0.80 mmol) and HOAT (181 mg, 1.33 mmol) in DCM (20 mL) was stirred at 0 , and DIPEA (0.37 mL, 2.13 mmol) was added dropwise. After the addition, the mixture was stirred at rt for 5 h. The mixture was concentrated. The residue was purified by silica gel chromatography eluted with Petroleum ether/EtOAc (v/v) 3/1 to give the title compound as colorless thick oil (260 mg, 70) .1H NMR (400 MHz, CDCl3) : delta ppm 7.55-7.62 (m, 2H) , 7.26 (d, J 8.4 Hz, 1H) , 6.72 (t, JF-H 75.1 Hz, 1H) , 5.25-5.29 (m, 1H) , 3.97-4.01 (m, 3H) , 3.79 (br. s, 1H) , 3.58-3.63 (m, 2H) , 1.50-1.52 (m, 3H) , 1.48 (s, 9H) , 1.45 (s, 9H) , 1.32-1.35 (m, 1H) , 0.68-0.73 (m, 2H) , 0.42-0.44 (m, 2H) and MS-ESI: m/z 695.3 [M+H] +.
As the paragraph descriping shows that 129799-15-1 is playing an increasingly important role.
Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
Piperazine – Wikipedia
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