With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163765-44-4,(R)-1-Boc-3-Methylpiperazine,as a common compound, the synthetic route is as follows.
7-Bromo-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridine-2-carbaldehyde (69-1) (1 g, 3.90 mmol) and (R)-tert-butyl 3-methylpiperazine-1-carboxylate (70-1) (0.935 g, 4.67 mmol) were dissolved in DCE (26 mL) and acetic acid (0.266 mL, 4.67 mmol) was added. The reaction was stirred for 30 min and sodium triacetoxyborohydride (4.13 g, 19.5 mmol) was added portionwise. After stirring for 16 hours the reaction was quenched by the slow addition of sat. sodium bicarbonate (100 mL) and extracted with DCM (2 x 100 mL). The combined organics were washed with brine, dried over sodium sulfate and concentrated. The residue was purified by column chromotagraphy (silica, 0-10 % MeOH in DCM) to give (R)-tert-butyl 4-((7-bromo-5- methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-2-yl)methyl)-3-methylpiperazine-1-carboxylate (70.2) (1.3 g, 76 %) as a white solid. LC/MS (ES+): m/z 440.8 [M + H]+, 163765-44-4
163765-44-4 (R)-1-Boc-3-Methylpiperazine 2756811, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; FITZGERALD, Mark, E.; MICHAEL, Ryan, E.; (790 pag.)WO2017/197056; (2017); A1;,
Piperazine – Wikipedia
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