With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-70-5,(S)-tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of 5-fluoro-2-methyl-3-nitrobenzaldehyde (D24 10 g) and (S) -tert-butyl 2-methylpiperazine-1-carboxylate (12.03 g) in DCM (120 mL) was added drops of acetic acid (3.28 g).The mixture was stirred at RT for an hour. Sodium triacetoxyhydroborate (23.15 g) was added in ice bath. The mixture was stirred at RT overnight and quenched with sat. NaHCO3solution. The organic layer was dried with anhydrous Na2SO4 filtered and concentrated in vacuo to give the title compound (22.17 g) as a syrup. MS (ESI) C18H26FN3O4requires 367 found 368 [M+H]+., 169447-70-5
The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; LEI, Hui; MA, Xin; REN, Feng; LIN, Xichen; MARQUIS, Robert W., Jr.; WO2015/180614; (2015); A1;,
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