With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78818-15-2,Benzyl 3-oxopiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
78818-15-2, l-(2-Hvdroxy-ethvn-4-r2-(lH-indazol-4-ylV4-morrhoholin-4-yl-thienor3,2- d]pyrimidin-6-ylmethyl”l-piperazin-2-one (87).Prepared via 4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6- ylmethyl)-l-(2-hydroxy-ethyl)-piperazin-2-one, prepared from l-(2-hydroxy-ethyl)- piperazin-2-one.Amine preparation: to 4-CBZ-piperazin-2-one (1.95g) in DMF (5mL) at O0C was added sodium hydride (60% dispersion in mineral oil, 660mg) in several aliquots. After stirring for 1 h, 2-bromoethylacetate (1.38ml) was added. The reaction mixture was stirred at room temperature overnight; it was then diluted with ethyl acetate, washed with brine, dried (MgSO4) and the solvent was removed in vacuo. The resulting residue was purified using flash chromatography to yield 4-(2-acetoxy- ethyl)-3-oxo-piperazine-l-carboxylic acid benzyl ester (925mg). 1H NMR (400MHz, J6-DMSO): 2.77 (2H, d, J=5.5Hz), 3.16 (2H, s), 3.32-3.36 (2H, m), 3.38-3.42 (2H, m), 3.51-3.55 (2H, m), 3.80-3.85 (4H, m), 3.97 (2H, s), 4.00-4.04 (4H, m), 4.70 (IH, t, J=5.4Hz, OH), 7.45 (IH, t, J=7.7Hz), 7.50 (IH, s), 7.66 (IH, d, J=8.2Hz), 8.22 (IH, d, J=7.3Hz), 8.89 (IH, s), 13.15 (IH, br, NH); MS (ESI+) 494 (MH+).
78818-15-2 Benzyl 3-oxopiperazine-1-carboxylate 736777, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; PIRAMED LIMITED; WO2006/46031; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics