5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5308-25-8, A mixture of 5-bromo-2-nitropyridine (1.02 g, 5.02 mmol) and 1 -ethylpiperazine (1 .71 g, 15.0 mmol) in N-methyl-2-pyrrolidinone (5 mL) was stirred at 120 C for 3 h. After this time, the reaction was cooled to room temperature, poured into water (100 mL) and extracted with methylene chloride (2 chi 100 mL). The combined organic layers were dried over sodium sulfate, filtered and the filtrate concentrated under reduced pressure. The resulting residue was purified by chromatography (silica, gradient, 1 :49 methanol/methylene chloride to 1 :9 methanol/methylene chloride) to afford l-ethyl-4-(6-nitropyridin-3- yl)piperazine as a yellow solid: 1H NMR (400 MHz, DMSO- )d 8.25 (d, J = 2.8 Hz, 1 H), 8.14 (d, J = 9.2 Hz, 1H), 7.48 (dd, J = 9.2, 2.8 Hz, 1H), 3.50-3.46 (m, 4H), 2.50-2.38 (m, 4H, merged with DMSO peak), 2.37 (q, J = 7.2 Hz, 2H), 1.02 (t, J= 7.2 Hz, 3H).
5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; GILEAD SCIENCES, INC.; BLOMGREN, Peter; CURRIE, Kevin, S; KROPF, Jeffrey, E.; LEE, Seung, H.; MITCHELL, Scott, A.; SCHMITT, Aaron, C.; XU, Jianjun; ZHAO, Zhongdong; WO2011/112995; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics