The synthetic route of 50606-32-1 has been constantly updated, and we look forward to future research findings.
50606-32-1, Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
50606-32-1, PREPARATION 8: Preparation of piperazine-1-carboxylic acid methylamide 11 g (59 mmol) of N-butyloxycarbonylpiperazine was dissolved in 250 ml of anhydrous tetrahydrofuran, and then 20.6 ml (118 mmol) of N,N-diisopropylethylamine and 13.1 g (64.9 mmol) of 4-nitrophenylchloroformate were added thereto, followed by stirring under reflux for 1 hour. 177 ml of methylamine (2 M tetrahydrofuran solution) was added to the reaction, followed by stirring under reflux for 30 minutes. After completion of the reaction, the reaction solution was concentrated, after addition of 100 ml of water, and then extracted twice with 100 ml of dichloromethane. 30 ml of 4 N hydrochloric acid/l,4-dioxane solution was added thereto, followed by stirring for 5 hours at room temperature. A solid, which was produced from completion of the reaction, was filtered off and dried to obtain 9.53 g (53 mmol, yield of 90%) of the title compound as hydrochloride salt.1H NMR (DMSOd6, ppm); delta 9.28 (IH, bs), 7.94 (IH, bs), 3.52 (4H, m), 3.01 (4H, m), 2.57 (3H, s)FAB MS(m/e) = 144 [M+l]
The synthetic route of 50606-32-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; LG LIFE SCIENCES, LTD.; WO2007/58482; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics