With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142-64-3,Piperazine Dihydrochloride,as a common compound, the synthetic route is as follows.
A solution of anhydrous piperazine (1, 9.4 g, 0.11 mol) and piperazine dihydrochloride (2, 31.8 g, 0.20 mol) in ethanol (80 mL) was placed in a three-necked flask equipped with a magnetic stir bar and reflux condenser and was heated with vigorous stirring at 65 C for 3 h. Then benzyl chloride (12.6 g, 0.10 mol) was added dropwise over a period of 45 min to the reaction mixture, which was then refluxed for another 2h. The progress of the reaction was monitored by TLC. The mixture was cooled and the precipitated piperazine dihydrochloride (2) was recovered. The combined filtrate was concentrated under reduced pressure to give the N-benzylpiperazine hydrochloride, which was then treated with 4 M NaOH to pH > 12. The aqueous layer of crude N-benzylpiperazine was extracted with CHCl3 (3 ¡Á 50 mL). The combined organic extracts were dried over Na2SO4 and concentrated under reduced pressure. The crude product was purified by flash column chromatography on silica gel (1:5 MeOH-CH2Cl2) to give 4: Yield 18.3 g (95%); 1H NMR (500 MHz, CDCl3): delta 7.34-7.28 (m, 5H),3.57 (s, 2H), 3.23 (s, 4H), 2.77 (s, 4H); MS (ESI) m/z: 177 [M + H]+.Spectroscopic data are according to the literature.13, 142-64-3
142-64-3 Piperazine Dihydrochloride 8893, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Hu, Xiao; Chen, Hui; Wu, Wei-Jun; Wang, Wen-Ling; Wang, Jin; Journal of Chemical Research; vol. 40; 9; (2016); p. 519 – 520;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics