485841-52-9, (S)-1,2-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: Diisopropylethylamine (215mul, 1.25mmol) was added to a solution of compound17a(300mg, 0.54mmol) in DMF (6ml), followed by Dimethylamine dihydrochloride (61mg, 0.75mmol), HOBt (7mg, 0.05mmol) and EDC/HCl (116mg, 0.60mmol). The solution was stirred for 16h at room temperature. The reaction mixture was diluted with saturated aqueous sodium bicarbonate, and extracted with EtOAc. The organic layer was washed with brine (3 times), and dried over magnesium sulfate. The mixture was filtered, and the solvent was removed in vacuo to afford the crude product. The residue was purified by flash silica gel chromatography with CHCl3/MeOH (30:1, v/v) to give the pale orange solid (116mg, 40% yield), which was precipitated from Et2O/n-hexane;
485841-52-9, 485841-52-9 (S)-1,2-Dimethylpiperazine 28305740, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Miyazaki, Masaki; Naito, Hiroyuki; Sugimoto, Yuuichi; Yoshida, Keisuke; Kawato, Haruko; Okayama, Tooru; Shimizu, Hironari; Miyazaki, Masaya; Kitagawa, Mayumi; Seki, Takahiko; Fukutake, Setsuko; Shiose, Yoshinobu; Aonuma, Masashi; Soga, Tsunehiko; Bioorganic and Medicinal Chemistry; vol. 21; 14; (2013); p. 4319 – 4331;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics