With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.
To a solution of 1-(2-hydroxyethyl) piperazine (1.0g, 7.686mmol) in dichloromethane (25mL) were added di-tert butyl dicarbonate (2.013g, 9.223mmol) and triethylamine (TEA, 2.130g, 15.372mmol). The reaction mixture was stirred at room temperature for 12h, then washed with 3% HCl aqueous (2¡Á50mL), saturated NaHCO3 aqueous (2¡Á50mL), brine (2¡Á50mL). The resulting organic layer wasdried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with dichloromethane/methanol (40:1) to form 1-Boc-4-(2-hydroxyethyl)-piperazine a colorlessoil (1.592g, 90% yield).
103-76-4, As the paragraph descriping shows that 103-76-4 is playing an increasingly important role.
Reference£º
Article; Hu, Caijuan; Su, Hao; Luo, Jinghan; Han, Li; Liu, Qingyin; Wu, Wenxi; Mu, Yu; Guan, Peipei; Sun, Tiemin; Huang, Xueshi; Bioorganic and Medicinal Chemistry; vol. 26; 23-24; (2018); p. 6035 – 6049;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics