With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2815-34-1,trans-2,5-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
A mixture of 0.20 g (0.38 mmol) 2- (3, 5-BIS-TRIFLUOROMETHYL-PHENYL)-N- [6-CHLORO-4- (4- fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide, 87 mg (0.75 mmol) (2RS, 5SR) -dimethyl-piperazine, 0.01 g (0.03 mmol) cetyltrimethylammonium bromide, 0.01 g (0.02 mmol) bis (tri-t-butylphosphine) palladium (0), 0.075 ml NaOH 50 % and 3 ml toluene was degassed by two freeze-thaw cycles. The reaction mixture was heated under argon at 90 C for 48 h. After cooling to room temperature the mixture was diluted with water and brine and extracted with three portions of tert-butyl methyl ether. The combined organic layers were dried over sodium sulphate and concentrated in vacuo. Flash column chromatography gave 96 mg (42%) of the title compound as a light yellow solid. MS m/e (%): 611 (M+H+, 100)
2815-34-1, As the paragraph descriping shows that 2815-34-1 is playing an increasingly important role.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/2577; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics