181955-79-3, 1,4-Di-Boc-piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 1,4-bis(tert-butoxycarbonyl)piperazine-2-carboxylic acid (4.88 g, 14.7 mmol) in DMF (49 mL) was added K2CO3 (2.65 g, 19.2 mmol), and the mixture cooled to 0 C. To the mixture was then slowly added methyl iodide (1.38 mL, 22.1 mmol). The reaction stirred was stirred at room temperature for 18 hours and quenched with saturated aqueous NH4Cl (100 mL). The mixture was diluted with water and extracted with EtOAc twice. The combined organic layers were washed with water and brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by column chromatography on SiO2 (Hex:EtOAc=7:1 to 5:1 to 3:1) to afford 1,4-di-tert-butyl 2-methyl piperazine-1,2,4-tricarboxylate (5.09 g, 100%) as a pale brown viscous oil. 1H-NMR (CDCl3, Varian, 400 MHz): delta 1.44 (18H, s), 2.80 (1H, br. s), 3.12-3.24 (1H, m), 3.21 (1H, br. s), 3.74 (3H, s), 3.80-4.10 (2H, m), 4.48-4.73 (2H, m).
181955-79-3, The synthetic route of 181955-79-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; HANDOK INC.; CMG Pharmaceutical Co., Ltd.; Kim, Moonsoo; Lee, Chaewoon; Lee, Gilnam; Yoon, Cheolhwan; Seo, Jeongbeob; Kim, Jay Hak; Lee, Minwoo; Jeong, Hankyul; Choi, Hyang; Jung, Myung Eun; Lee, Ki Nam; Kim, Hyun Jung; Kim, Hye Kyoung; Lee, Jae Il; Lee, MinWoo; Kim, Misoon; Choi, Soongyu; (124 pag.)US2016/168156; (2016); A1;,
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