With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.
0Example 1 4- [6- (4-ISOPROPYLPIPERAZIN-1-YL)-PYRIDAZIN-3-YL] BENZONITRILE A suspension OF 4- (6-CHLORO-PYRIDAZIN-3-YL)-BENZONITRILE (1 g, 4.64 mmol ; prepared as de- scribed in US patent No. 4,112, 095), isopropylpiperazine (0.654 g, 5.1 MMOL), DIPEA (1.199 g, 9.27 MMOL) and 4- (DIMETHYLAMINO) PYRIDINE (0.057g, 0.464 MMOL) in DMSO (4 mi) was stirred and heated to 100 ¡ãC for 20h. After cooling to room temperature, the mixture was di- luted with DICHLOROMETHANE (25 ml) and water (35 ml) and stirred for 5 min. The organic phase was separated, washed with water (50 ml) and brine (50 ML), and acidified to pH 2 by addition of 1 N hydrochloric acid. The mixture was extracted with water (30 ML), and the aque- ous phase was washed with DICHLOROMETHANE (10 mi) and concentrated in vacuo to give a solid, which was collected and stripped with ethanol to afford the title compound as a crys- talline hydrochloride (1.33 g, 76percent). ‘H NMR (D2O) 51. 30 (d, 6H), 3.26 (broad t, 2H), 3.45-3. 68 (m, 5H), 4.52 (broad d, 2H), 7.75 (d, 1H), 7.77 (d, 2H), 7.87 (d, 2H), 8.12 (d, 1H) ; HPLC-MS: M/Z 308.2 (MH+) ; Rt : 1.76 min., 4318-42-7
The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVO NORDISK A/S; WO2005/9976; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics